Running head: PENICILLIN 1 Penicillin Gurdeep Kaur Atwal South University Online FNP NSG6005 9/8/2018 Penicillin’s Classification Penicillin’s are in the family of antibiotics known as beta-lactams. These medications have a four-member ring known as beta-lactam. All such antibiotics are considered to be bactericidal when they are administered in a concentration of more than the minimum inhibitory amount of the microbes (roughly 50% of the dosing interval). These antibiotics are more efficient in actively multiplying organisms because of new cell walls formation (Woo and Robinson, 2015). Some bacteria develop beta-lactamase enzymes that are capable of breaking (hydrolyze) the beta-lactam ring; thus, rendering the antibiotics less effective. Therefore, some penicillin’s are combined with penicillinase inhibitors which enable them to cover a wide range of microorganisms and achieve reduced resistance. Other antibiotics that are made of beta-lactam ring include cephalosporins, monobactams, and carbapenems. All penicillin’s have the basic structure known as 6-aminopenicillin acid nucleus that is important for biological activities of this compounds (Woo and Robinson, 2015). The replacement of different substitutes along 6- aminopenicillin acid chain gives various classes of penicillin’s: Natural penicillin’s (example pen G) have great activity against gram-
PENICILLIN 2 negative cocci, gram-positive microbes, and non-beta-lactamase producing anaerobes. Anti-staphylococcal penicillin’s (such as floxacillin and cloxacillin) are resistant to staphylococcal beta-lactamase. They are effective against staphylococci and streptococci. Anti-pseudomonal penicillin’s like piperacillin have activity against P.
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