The idea that there is specific pairing of nitrogenous bases in DNA was the flash of inspiration that led Watson and Crick to the correct double helix and at the same time they saw the functional significance of the base-pairing rules.Prior to the duplication of the double helix, Watson and Crick believed that hydrogen bonds are broken down and the two chains are unwound and separated. They also stated in their hypothesis that, “each chain then acts as a template for the formation onto itself of a new companion chain.” In other words, what started off as only one single chain was developed or duplicated into two pair of identical chains. DNA replication was also proposed by Matthew Meselson and Franklin Stahl. They devised three separate experiments to test their hypothesizes and only one had plausible results. Meselson and Stahl concluded that DNA replication follows the semiconservative model by comparing their results to the results predicted by each of the
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