Semester 2 pharm FINAL study guide.docx - Pharm final study...

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Pharm final study guide PHARM FINAL STUDY GUIDE: *REMEMBER TO LOOK AT ATI BOOK QUESTIONS!!!* 10 CALCULATIONS 20 Q’s on Anti-infectives: Tetracycline and doxycycline  bacteriostatic antibiotic: protein synthesis inhibitors o Tetra cycline s, doxy cycline , mino cycline , demeclo cycline o Inhibit bacterial protein synthesis, bacteriostatic, broad spectrum txc of gram -/+, not often used due to overuse o Tx of: periodontal disease, acne, PUD, anthrax, lyme disease, rickettsia disease, mycoplasma pneumonia o Side effects: decreases effectiveness of OCP, causes photosensitivity (sunburns), causes super infections (diarrheas and yeast), can cause permanent discoloration in teeth, do not give to children < 8 years old , can cause staining of deciduous teeth in infants if given after 4 th month of pregnancy, teratogenic in 1 st trimester of pregnancy (PREG cat D), keep drug out of heat & lip o Teaching: reduced absorption: should not be taken within 2 hrs of dairy products, soy, supplements, antacids with Ca, Fe, Mg or Al. take tetracycline on empty stomach with 8 oz of water, both minocycline and doxycycline increase risk of digoxin toxicity. Antibiotic families with Beta Lactamase ring and why
Pharm final study guide On cephalosporin slide: Resistance- Beta-lactamases (cephalosporinases) Third- and fourth-generation agents more resistant than first- and second-generation agents Flaygl  antiprotozoal agent and treats infections caused by anaerobic bacteria o Tx of organisms in the GI tract: C. Diff, H. Pylori, traveler’s diarrhea, BV, trichomoniasis & prophylaxis for vaginal, abdominal and colorectal sx o Broad spectrum: alters bacterial DNA, bactericidal effects, inhibits CYP enzyme o Side effects: GI discomfort (N/V) take with meals, pseudomembranous colitis, interferes with OCPs, cause urine to be brown/red, bitter/metallic taste in mouth o Contraindicated in acute CNS disorders, blood dyscrasias, lactation and 1 st trimester of pregnancy, use caution in clients with kidney, cardiac fungal or candida infections, elderly, clients in 2 nd or 3 rd trimester and seizure disorders, inhibits inactivation of warfarin, phenytoin, and lithium, thus increase levels of these drugs. NO ETOH  disulfiram reaction (severe N/V). Permethrin: (nix, elimite, acticin) o Tx: mites, lice and their ova (also fleas and ticks) o Resistance = 50% failure with head lice
Pharm final study guide o Residual activity up to 2 weeks after txc o Only one application requires o Approved for age 2 months and older o Devoid of serious side effects Zyvox: linezolid (Zyvox) bacteriostatic antibiotic o Reserved for MRSA & VRE only o Inhibits protein synthesis much earlier than other abx-static o Cross-resistance with other agents unlikely o Can cause myelosuppression, HTN crisis (weak MAO inhibitor), serotonin syndrome o Interacts with MAOIs (nardil, parnate) Vancomycin: glycopeptide o Destroys bacterial cell walls of micro-organisms o Used for severe infections only, MRSA, staphylococcus epidermis

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