Ford_PPT_Ch_08 pharm.ppt - Introduction to Clinical Pharmacology Chapter 8 Antibacterial Drugs That Interfere With Protein Synthesis Copyright 2014

Ford_PPT_Ch_08 pharm.ppt - Introduction to Clinical...

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Introduction to Clinical Pharmacology Chapter 8 Antibacterial Drugs That Interfere With Protein Synthesis Introduction to Clinical Pharmacology Chapter 8 Antibacterial Drugs That Interfere With Protein Synthesis
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Anti-infectives composed of natural and semisynthetic compounds Actions: Inhibit bacterial protein synthesis Used as broad-spectrum antibiotic when penicillin is contraindicated Treat the following infections: Rickettsial diseases; intestinal amebiasis; skin and soft tissue infections; uncomplicated urethral, endocervical, or rectal infections; adjunctive treatment; and infection with Helicobacter pylori Tetracyclines
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Gastrointestinal/other body system reactions: Nausea and/or vomiting Diarrhea Epigastric distress Stomatitis Sore throat Skin rashes Photosensitivity reaction Tetracyclines: Adverse Reactions
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Contraindicated in patients: With hypersensitivity; during pregnancy, lactation; children younger than 9 years Nursing alert: Not given to children younger than 9 years of age Prolonged therapy: Bacterial/fungal overgrowth of nonsusceptible organisms Tetracyclines: Contraindications
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Used cautiously in patients with: Impaired renal function Liver impairment Chronic care alert: May increase the risk of digitalis toxicity in patients who take digitalis drugs for heart disease Tetracyclines: Precautions
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Tetracyclines: Interactions Interacting drug Effect of interaction Antacids containing aluminum, zinc, magnesium, or bismuth salts Decreases effectiveness of tetracyclines Oral anticoagulants Increases risk for bleeding Oral contraceptives Decreases effectiveness of contraceptive agent
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Tetracyclines: Interactions (cont.) Interacting drug Effect of interaction Digoxin Increases the risk for digitalis toxicity Calcium-rich foods Causes potentially impaired absorption of tetracycline
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Aminoglycosides: Actions and Uses Aminoglycosides: Actions and Uses Blocks step in protein synthesis necessary for bacterial multiplication Used against gram-negative microorganisms Bowel preparation Hepatic coma
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Aminoglycosides: Adverse Reactions Aminoglycosides: Adverse Reactions Nausea Vomiting Anorexia Rash Urticaria Nephrotoxicity (damage to the kidneys by a toxic substance) Ototoxicity (damage to the hearing organs by a toxic substance) Neurotoxicity (damage to the nervous system by a toxic substance)
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