Generic Name:LovenoxClassifications:Chemical class:Low-molecular-weight heparin: Therapeutic class:Antithrombotic: Pregnancy category:BUse:Prevention of deep vein thrombosis (DVT) after hip, knee, or abdominal surgery, treatment of DVT and pulmonary embolism, myocardial infarction (STEMI), unstable angina, non-Q wave MI.Action:Potentiates the action of antithrombin III, a coagulation inhibitor. By binding with antithrombin III, enoxaparin rapidly binds with and inactivates clotting factors (primarily thrombin and factor Xa). Without thrombin, fibrinogen can’t convert to fibrin and clots can’t form.Route & Dosage:Subcutaneous injection- To prevent deep vein thrombosis (DVT) after hip or knee replacement and for continued prophylaxis after hospitalization for hip replacementAdults.- 30 mg every 12 hr, starting 12 to 24 hr after surgery for up to 14 days. Or, 40 mg daily, starting 9 to 15 hr after hip replacement surgery. Prophylaxis:40 mg daily for 3 wk.Subcutaneous injection- To prevent DVT after abdominal surgery for patients with thromboembolic risk factors (over age 40, obesity, general anesthesia lasting longer than 30 minutes, cancer, or a history of DVT or pulmonary embolism)Adults.- 40 mg daily, starting 2 hr before surgery and lasting 7 to 10 days. Subcutaneous injection-To prevent ischemic complications of unstable angina and non–Q-wave MIAdults- 1 mg/kg every 12 hr with 100 to 325 mg of aspirin daily for 2 to 8 days or until condition is stable.
