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Unformatted text preview: ACTIVE LEARNING TEMPLATE: Medication Charity Biddy
MEDICATION___________________________________________________________________________ REVIEW MODULE CHAPTER____________
_____________________________________________________________________ PURPOSE OF MEDICATION Expected Pharmacological Action
Inhibition of viral replication, decreased viral
shedding, and reduced time for healing of lesions. Therapeutic Use
Treatment of genital herpes Complications
CNS: seizures, dizziness, HA, hallucinations, trembling GI: diarrhea, nausea, vomiting, ↑ liver
enzymes, hyperbilirubinemia, abdominal pain, anorexia GU: Renal Failure, crystalluria,
hematuria, renal pain Derm: Stevens-Johnson Syndrome, acne, hives, rash, unusual sweating
Endo: changes in menstrual cycle Hemat: THROMBOTIC THROMBOCYTOPENIC
PURPURA/HEMOLYTIC UREMIC SYNDROME (HIGH DOSES IN IMMUNOSUPPRESSED
PATIENTS) Local: pain, phlebitis, local irritation MS: joint pain Misc: polydipsia Medication Administration
Initial Genital Herpes PO: (Adults and Children) 200 mg q 4 hr
while awake (5 times/day) for 7–10 days or 400 mg q 8 hr for
7–10 days; maximum dose in children: 80 mg/kg/day in 3–5
divided doses. IV: (Adults and Children) 5 mg/kg q 8 hr or 750
mg/m2 /day divided q 8 hr for 5–7 days.
Chronic Suppressive Therapy for Recurrent Genital Herpes
PO: (Adults and Children) 400 mg twice daily or 200 mg 3–5
times/day for up to 12 mo. Maximum dose in children: 80
mg/kg/day in 2–5 divided doses.
Intermittent Therapy for Recurrent Genital Herpes PO: (Adults
and Children) 200 mg q 4 hr while awake (5 times/day) or 400
mg q 8hr or 800 mg q 12 hr for 5 days, start at first sign of
symptoms. Maximum dose in children: 80 mg/kg/day in 2–5
divided doses. Contraindications/Precautions
Contraindicated in: Hypersensitivity to acyclovir or valacyclovir; Hypersensitivity to milk
protein concentrate (buccal only) Use Cautiously in: Pre-existing serious neurologic,
hepatic, pulmonary, or fluid and electrolyte abnormalities; Renal impairment (dose
alteration recommended if CCr <50 mL/min); Geri: Due to age related ↓ in renal function;
Obese patients (dose should be based on ideal body weight); Patients with hypoxia;
OB: Lactation: Safety not established. Interactions
Probenecid ↑ blood levels of acyclovir.
↑ blood levels and risk of toxicity from theophylline; dose adjustment may be necessary.
↓ blood levels and may ↓ effectiveness of valproic acid or phenytoin .
Concurrent use of other nephrotoxic drugs ↑ risk of adverse renal effects.
Zidovudine and IT methotrexate may ↑ risk of CNS side effects. Nursing Interventions
Assess lesions before and daily during therapy.
Assess frequency of recurrences.
Monitor neurologic status in patients with
Lab Test Considerations:
Monitor BUN, serum creatinine, and CCr
before and during therapy. ↑ BUN and serum
creatinine levels or ↓ CCr may indicate renal
failure. Client Education
Evaluation of Medication Effectiveness Crusting over and healing of skin lesions.
Decrease in frequency and severity of recurrences.
Acceleration of complete healing and cessation of pain in
herpes zoster. ACTIVE LEARNING TEMPLATES Take as directed for the full course. Use of
additional OTC creams, lotions, ointments may
delay healing and spread lesions. This is not a
cure, the virus lies dormant in ganglia and will
not prevent spread of infection to others.
Condoms should be used during sexual contact
and no sexual contact when lesions are present.
call HCP if symptoms not improved in 7 days.
Women should have yearly Pap smears d/t more
likely to develop cervical cancer. Therapeutic Procedure A7 ...
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