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Post an explanation of circumstances under which children should be prescribed drugs for off-label use. Then, describe strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Include descriptions and names of off-label drugs that require extra care and attention when used in pediatrics.Main PostExplanation of off label useIn general, before a drug is approved for use by the FDA, its efficacy and safety are evaluated by conducting clinical trials on highly selected populations. Children are not sufficiently represented in clinical trials because of safety issues; these drugs, however, have to be administered to children in clinical practice(Rollins DE, et.al. 2016). This is where the term "Off-label" come into the picture. Off label means the medication is being used in a manner not specified in the FDA's approved packaging label, or insert. Every prescription drug marketed in the U.S. carries an individual, FDA-approved label (Miller, K., 2018). Many pediatricians must prescribe drugs off-label, simply because an overwhelming number of critical drugs still have no information on the label for use in children. StrategiesDosage guidelines are not available for most drugs in children, so the empirical dose adjustment method is used to determine the appropriate dosage. Dosage should be based on the child’s age or body weight using the adult drug dosages as guidance. Young’s rule [Adult Dose ×