Professor Smalls Lecture 25.docx - Professor Smalls Lecture 25[Evolution 2 Convergent evolution Mutations in different genes can lead to similar

Professor Smalls Lecture 25.docx - Professor Smalls Lecture...

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Professor Smalls Lecture 25 [Evolution 2]: Convergent evolution – Mutations in different genes can lead to similar phenotypes. We use the example of mice in Florida, and fur color, for this phenomenon. Mice from island areas of Florida had whiter coats –which matched the sand – than that of the coats of mainland mice, who had dark coats. There is a good correlation between the frequency of the C65 allele and the light color coats of mice near Santa Rosa Island. Mice near the Atlantic coast of Florida also have white coats – however, no evidence proves that the same mutation that affected Santa Rosa mice, affected mice from the Atlantic side, even though both groups have white coats. Other mutations must have caused loss of coat color in the Atlantic population. Mc1R encodes a G-Receptor protein It interacts with adenylyl cyclase, which leads to cAMP production to help produce melanin. We know that the Santa Rosa mice have mutated McR1 protein receptor. We don’t know what the Atlantic mice have mutated, that’s causing them to lose coat color (it could be a mutation anywhere in the protein signaling pathway, such as the signal, the G-protein, the adenylyl cyclase, the cAMP, or the protein kinase A). It’s reasonable to think that mating light colored mice from both Atlantic coast, and Santa Rosa, would yield several dark colored mice.
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