Chapter_59.ppt - Chapter 59 Antiemetic Agents Copyright 2013 Wolters Kluwer Health | Lippincott Williams Wilkins Nausea and Vomiting Most common and

Chapter_59.ppt - Chapter 59 Antiemetic Agents Copyright...

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 59: Antiemetic Agents Chapter 59: Antiemetic Agents
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Nausea and Vomiting Nausea and Vomiting Most common and most uncomfortable complaints. Vomiting is a complex reflex reaction to various stimuli. In some cases, it may be desired to induce vomiting. In many clinical conditions, the reflex reaction of vomiting is not beneficial.
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Managing Nausea and Vomiting Managing Nausea and Vomiting Emetics Cause vomiting No longer recommended for at-home poison control Antiemetics Decrease or prevent nausea and vomiting Centrally acting or locally acting Varying degrees of effectiveness
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Sites of Action of Emetics/Antiemetics Sites of Action of Emetics/Antiemetics
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Use of Drugs Affecting the Female Reproductive System Antiemetic Agents Across the Lifespan Reproductive System Antiemetic Agents Across the Lifespan
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Groups of Centrally Acting Antiemetics Groups of Centrally Acting Antiemetics Phenothiazines Nonphenothiazines Serotonin (5-HT 3 ) Receptor Blockers Substance P/Neurokinin 1 Receptor Antagonists Miscellaneous Group
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Phenothiazines Phenothiazines Antianxiety drug that blocks the responsiveness of the CTZ to stimuli, leading to a decrease in nausea and vomiting Prochlorperazine (generic) Chlorpromazine (generic) Perphenazine (generic)
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Phenothiazines Phenothiazines Actions Depresses various areas of the central nervous system (CNS) Indications Treatment of nausea and vomiting Adverse Effects Drowsiness
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Prototype Phenothiazines Prototype Phenothiazines
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