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CH16: Anti-Inflammatory, Anti-arthritis, and Related AgentsPropertySalicylates(Aspirin)NSAID’s(Ibuprofen)Related Agent(Acetaminophen)DescriptionAnti-inflammatory agent drug that block the effects of the inflammatory response. Salicylic acid compounds with anti-inflammatory, antipyretic (fever-blocking),and analgesic (pain-blocking)properties.Nonsteroidal anti-inflammatory drugs (NSAIDs) provide strong anti-inflammatoryand analgesic effectswithout the AE A/W corticosteroids. A/W cardiovascular and gastrointestinal risks when taking them.Acetaminophen is a related drug which has antipyretic and analgesicpropertiesbut does not have the anti-inflammatory effectsof the salicylates or the NSAIDs.ActionInhibits synthesis of prostaglandin, aninflammatory reaction mediator, relieves the signs and symptoms of inflammation.Antipyretic - blocking of prostaglandin mediator of pyrogens (chemicals released by active white blood cells that cause increase in body temperature) at the thermoregulatory center of the hypothalamus.Low levels reduce platelet aggregation by inhibiting synthesis of thromboxane A2, a potent vasoconstrictor that normally increases platelet aggregationand blood clot formation. High levels inhibit the synthesis of prostacyclin, a vasodilator that inhibits platelet aggregation.Inhibition of prostaglandin synthesis thereby exerting its anti-inflammatory, analgesic, and antipyretic effects.Blocks two enzymes, cyclooxygenase(COX) 1 and 2 present in all tissues and involved in many body functions, i.e. blood clotting, stomach lining, and sodium-water balance in the kidney. COX-1 turns arachidonic acid into prostaglandins as needed. COX-2 is active at sites of trauma or injury when more prostaglandins are needed. NSAIDs block inflammation before all of the S/S can develop.Acts directly on the thermoregulatory cells in the hypothalamus to cause sweatingand vasodilation causing release ofheat. The mechanism related to analgesic effects has not been identified.IndicationsIndicationsTreatment of mild to moderate pain, fever, numerous inflammatory conditions(e.g., rheumatoid arthritis and osteoarthritis).Mesalamine and balsalazide - ulcerative colitis and other Relief of S/S of rheumatoid arthritisand osteoarthritisRelief of mild to moderate painTreatment of primary dysmenorrhea, pain, HA, inflammationTx moderate/mild pain & fever in children,often used in place of the NSAIDs or salicylates. Tx influenza, prophylaxis of children receiving diphtheria-pertussis-tetanus (DPT) Page | 1
CH16: Anti-Inflammatory, Anti-arthritis, and Related AgentsPropertySalicylates(Aspirin)NSAID’s(Ibuprofen)Related Agent(Acetaminophen)inflammatory bowel conditions.