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NURS 6521 Week 1 Initial Discussion PostPharmacodynamics and PharmacokineticsIt is very important for Advanced Practice Nurses to understand that pharmacodynamicsand pharmacokinetics of drugs. According to Arcangelo and Peterson (2013), pharmacodynamicsrefers to how the drug affects the body including its therapeutic and toxic effects both on cellularand systemic level, while pharmacokinetics refers to how the body affects the drug includingadministration, absorption, distribution, and elimination from the body. Arcangelo and Peterson(2013) discussed the importance of understanding that knowing the blood concentration is veryimportant even though the most important to know is how the amount of drug that reaches thereceptor or site of action affects the pharmacodynamics and pharmacokinetics. There are manyfactors that could affect how the body responds to drugs.Description of Case SelectedMrs DJ was a 75 year old patient who was admitted for a fractured femur and persistentdiarrhea after a course of antibiotics to treat a urinary tract infection. The patient was having somuch diarrhea that it was difficult for her to get some sleep. Her daughter stated that the patienttakes diphenhydramine (Benadryl) for sleep at home and requested for her to have a sleep aid.