PK Definitions Terminology, Plasma Level Time Curve Fall 2018 - 2019.pdf - Pharmacokinetics Definitions Terminology Plasma Level Time Curve Nabil B

PK Definitions Terminology, Plasma Level Time Curve Fall 2018 - 2019.pdf

This preview shows page 1 - 13 out of 46 pages.

Pharmacokinetics Definitions & Terminology, Plasma Level Time Curve Nabil B. Darwazeh, Ph.D.
Image of page 1
Biopharmaceutics : the science that examines the interrelationship of: The physicochemical properties of the drug, e.g., solubility, stability, polymorphism. The dosage form in which the drug is given, e.g., rate of dissolution/release The route of administration on the rate and extent of systemic drug absorption (Boiavailability), e.g. systemic absorption of the drug. Definitions and Terminology
Image of page 2
Biopharmaceutics : Definitions and Terminology Scheme demonstrating the dynamic relationship between the drug, the drug product, and the pharmacologic effect.
Image of page 3
Biopharmaceutics examines the interrelationship between: Definitions and Terminology Biopharmaceutics Dosage Forms; Tablet, Liquid, Injection Rout of Admiration, oral, IV, SC, IP, TD Drug Physical / Chemical Properties
Image of page 4
Pharmacokinetics = Pharmaco + Kinetics Pharmacon = Greek word for drugs and poisons Kinetics = Dynamics Movement of drug in the body Rate of Change of drug = Unit of Concentration per Unit of time Pharmacokinetics is the science of what the biological body does to a chemical Definitions and Terminology
Image of page 5
Pharmacokinetics is the science of the kinetics of drug A bsorption, D istribution, M etabolism, and E limination (ADME). Definitions and Terminology
Image of page 6
Absorption The process by which the drug is removed from its site of application into the blood stream. Must take place for the drug molecules to reach the systemic circulation (Extravascular Administration). Pharmacokinetics and ADME
Image of page 7
Absorption : In case of intravascular drug administration, the drug molecules directly reach the systemic circulation Pharmacokinetics and ADME
Image of page 8
Distribution is the process of reversible transfer of drug to and from the site of measurement (Blood or Plasma). Drugs are in a dynamic state within the body as they move between tissues and fluids, bind with plasma or cellular components, or are metabolized. Any drug that leaves the site of measurement and does not return has undergone elimination. Pharmacokinetics and ADME
Image of page 9
Metabolism is the process of a conversion of one chemical species to another chemical species. Usually, metabolites have little or no activity of the parent drug. However, there are exceptions, some drugs with therapeutically active metabolites. Pharmacokinetics and ADME
Image of page 10
Pharmacokinetics and ADME Metabolites have little or no activity of the parent drug Metabolism
Image of page 11
Procainamide is metabolized by N-acetylation forming an active metabolite N-acetyl procainamide which shows class III activity. Procainamide is a class Ia antiarrhythmic agent that also shows class III activity by blocking the potassium channels.
Image of page 12
Image of page 13

You've reached the end of your free preview.

Want to read all 46 pages?

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture