L01 - Introduction - Cell and Water.pdf

L01 - Introduction - Cell and Water.pdf - Lecture 1...

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1/6/2019 1 Learning Objectives 1) Brief introduction of biochemistry 2) pH and pKa in water Lecture 1. Introduction Chapter 1, 2 Biochemistry : The study of the chemistry of life processes Salmonella Yeast How living things function at a biochemical (molecular) level
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1/6/2019 2 All Living Organisms Build from Monomeric Subunits Understanding biomolecular structure and function , which is the essence of biochemistry structure of water: bent - + polar! Water interacts with polar molecules via H bond and electrostatic interactions.
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1/6/2019 3 pH pH is a logarithmic scale used as a measure of the H + concentration of a solution (acidity of solution) pH = log = -log[H + ] 1 [H + ] H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + H + [H + ] = 10 -4 M pH = 4 pH = 2 pH = 0 Acidity? [H + ] = 10 -2 M [H + ] = 1 M H + H + H + H + H + H + pK a pK a is a logarithmic scale that applies to a specific functional group of a molecule , and is a measure of the acidity (tendency to dissociate a proton): pK a = log = -log[K a ] 1 [K a ] K a is a dissociation constant
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