2. Kraus, Drugs

2. Kraus, Drugs - Developing Aptamers to Methamphetamine...

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Unformatted text preview: Developing Aptamers to Methamphetamine Marit Nilsen-Hamilton, Biochemistry, Biophysics and Molecular Biology George Kraus, Chemistry Project goals- Aptamers will be selected that specifically recognize methamphetamine for the development of a highly sensitive fluorescence-based assay Specific aims : 1) isolate aptamers specific for methamphetamine 2) characterize the isolated aptamers. Long-term goal- to produce aptamers that can be used as a screening tools for a variety of drugs to provide forensics investigators with a rapid accurate screening procedures for common drugs The Methamphetamine Problem in Iowa Iowa was number one in meth lab seizures per capita in 2004 Meth makers use ammonia, lithium from batteries and pseudoephedrine from cold remedies Over 12,000 people in Iowa over age 12 have reported meth use Ph NHMe Me HO Ph NHMe Me Li NH 3 Meth reaction HCl Design of Inhibitors of Meth Production Objectives: The goal of this project is to identify inexpensive and non-...
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2. Kraus, Drugs - Developing Aptamers to Methamphetamine...

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