Parkinson’s Disease.docx - Parkinsons Disease...

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Parkinson’s Disease; Degenerative disease of the CNS Parkinson’s Disease o Defined as a complex, chronic, progressive, neurodegenerative illness resulting from the slow loss of the brain’s dopamine producing system o Due to the degeneration of dopamine producing cells in the substantia nigra (part of the midbrain) o Imbalance in dopamine and acetelcholine affects voluntary movement All About Parkinson’s o Most common hypokinetic movement disorder o Movement disorder for which we have the most understanding. o Four decades ago, PD was thought to be caused simply by a shortage of dopamine producing cells in the substantia nigra. o Now it is known that this is only a piece of the puzzle. o Affects men slightly more than women o Not a reportable disorder in the US o Can occur at any age, but most commonly diagnosed in the 5 th or 6 th decade of life Not Just A Movement Disorder Anymore… o Motor symptoms o Non-motor symptoms o Neuro-psychiatric symptoms Dr. James Parkinson o In 1817 described what he called a “shaking palsy.” o Described people with : Tremor at rest Stooped posture Shuffling gait Tendency to go from a walking to a running pace. o Interesting Facts Dr. Parkinson’s first three cases were 52, 62, and 65 years old. He attributed one patient’s symptoms to alcohol consumption, and another’s to sleeping on the hard cold ground. Many early scientists believed PD was a normal phenomenon of aging. Neurotransmitter Therapy o With the discovery of neurotransmitters it was learned that a decrease in the number of dopamine producing cells was contributing to the symptoms. o For a while, many scientists believed that the disease was simply an imbalance of dopamine and its excitatory neurotransmitter partner (Acetylcholine) Idopathic Parkinson’s o Although the mechanism by which the disease occurs is well understood, the actual cause of the disease is unknown. Secondary Parkinson’s o Secondary Parkinson’s related to trauma, drug induced, post encephalitic Theories About The Cause o Viral infection o Blows to the head o Brain infectio
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o Atherosclerosi o Exposure to certain drugs/toxins o Environmental factors Awakenings- Base of the Movie o
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  • Spring '14
  • Brinkley
  •  Tremor

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