Coronary Atherosclerosis and Coronary Artery Disease.docx

Coronary Atherosclerosis and Coronary Artery Disease.docx -...

This preview shows page 1 - 3 out of 7 pages.

Coronary Atherosclerosis and Coronary Artery Disease CVD,CAD, Angina Pectoris Coronary Artery Disease o Restriction of blood flow in the coronary arteries o Myocardium is deprived of oxygen-rich blood o Most common cause of restriction of blood flow is atherosclerosis o Main symptom of CAD is Angina Pectoris Atherosclerosis o Characterized by atheroma (plaque deposits): an abnormal accumulation of lipid or fatty substances and fibrous tissue in the vessel wall. o This process results in CAD o It is a progressive disease which can be curtailed and in some cases reversed. Risk Factors of CAD o Non-modifiable Age Gender Genetic factors Family behaviors Family history Ethnic background o Modifiable Smoking Poor nutrition Obesity Stressful life-style Physical inactivity o Others Hypertension Hyperlipidemia: excessive amounts of lipids (fats) in the blood stream Diabetes: Glucose intolerance Metabolic syndrome: abdominal obesity, hyperlipidemia, insulin resistance, > tendency for clotting and inflammation Female risk factors: oral contraceptives, HRT, premature menopause Lipid Profile o Standard lipid profile measures total cholesterol high density lipoprotein (HDL) low density lipoprotein (LDL) Cholesterol Levels o > 240 : high risk for cardiac event o 200-239 : borderline high risk for cardiac event o <200 : low risk for cardiac event o Cholesterol is produced by the liver-helps to build healthy cells. Present in some foods Lipoproteins: LDL o Carry cholesterol in the blood stream o LDL :“bad cholesterol”: increased levels, increased risk o Desirable low levels <100 mg/dl o Methods to lower LDL: diet, exercise, pharmacological agents Lipoproteins: HDL o Carry cholesterol in the blood stream o HDL: “good cholesterol”, believed to assist in the removal of excess cholesterol from the body and block uptake of LDL o Desirable level: > 60 mg/dl
Image of page 1

Subscribe to view the full document.

o Methods to raise HDL: diet exercise, weight loss o Medications o Please refer to Smeltzer text p. 761 o Medications affecting lipoprotein metabolism. o If diet alone does not control cholesterol, med might need to be added. Antihyperlipidemic Agents (2) o 1. HMG-CoA Reductase Inhibitors (statins) Simvastatin /Zocar Lovastatin / Mevacor Pravastatin / Pravachol Decrease the manufacture of cholesterol in the liver by enzyme inhibition. Contraindicated in liver disease Maximum effects may take up to 6 weeks o 2. Bile-Acid Sequestrants Cholestramine / Questran Binds bile acids (Cholesterol) in the intestines into insoluble complexes for excretion in the stool.
Image of page 2
Image of page 3
You've reached the end of this preview.
  • Spring '14
  • Brinkley
  • Atherosclerosis, stable angina, angina pectoris,  Simvastatin

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern