Cellular Regulation.docx - Cellular Regulation Oncology...

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Cellular Regulation: Oncology Concept: Cellular Regulation o Definition: Cellular regulation is the process by which the body cells Review of the Normal Cell o Distinct morphology o Orderly growth o Non-migratory o Programmed apoptosis o Contact inhibition o Differentiated function Alteration in Cellular Regulation: Cancer o Definition: a disease process whereby cells proliferate abnormally, ignoring growth-regulating signals in the environment surrounding the cells Epidemiology of CA o Incidence o Mortality o Survival rate Cancer Health Disparities o “Differences in the incidence, prevalence, mortality, and burden of cancer and related adverse health conditions that exist among specific population groups in the United States." Normal cell vs. Cancer cell o Distinct morphology o Orderly growth o Non-migratory o Programmed apoptosis o Contact inhibition o Differentiated function o Unregulated growth o Spread (metastasis) to other body cells and organs o Lack of differentiation Neoplasms (Tumors) o New growth that has no physiologic purpose o May be benign or malignant o Malignant tumors are cancerous. Benign Grow at wrong time, wrong location, locally Cause damage when they increase in size Cohesive Well defined borders Pushes other tissue aside Slow growth Easily removed Does not recur (typically) Malignant Rapid or continuous cell division Poorly differentiated Invade other tissues, no stop at tissue border Large irregular nucleus
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  • Spring '14
  • Brinkley
  • primary tumor,  Mechanisms of Metastasis,  Cause damage,  Staging

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