ARDS.docx - ARDS Acute(Adult Respiratory Distress Syndrome...

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ARDS Acute (Adult) Respiratory Distress Syndrome DEFINITION o ARDS is a state of acute respiratory failure or a disorder resulting from an acute lung injury. o ARDS is characterized by: Widespread bilateral pulmonary infiltrates Severe refractory hypoxemia Sudden and progressive non-cardiac pulmonary edema Reduced lung compliance Dyspnea ETIOLOGY o Identified in last 25 years o Common problem, 200 -250,000 cases yr o Mortality is 50-65% with treatment o Client often young and healthy o Septic shock is #1 risk factor o AID’s, Multiple organ failure, DIC have poor outcome Acute injury of alveolar capillary membrane=pulmonary edema o Direct damage to the alveolar-capillary gas exchange o Indirect damage caused by inflammatory mediators Predisposing Conditions o Infectious causes: Pneumonia,TB o Aspiration of fluids: gastric,drowning o Trauma: head injury, burns o Shock: any type o Inhaled toxic agents: smoke, gases o Drug overdose o Trauma: pulmonary contusion, head injury o Sepsis Initial damage starts inflammatory process o Initial injury stimulates platelet aggregation and intravascular thrombus formation o Platelets release substances that attract and activate neutrophils o Neutrophils release inflammatory mediators that cause all the damage, ex. proteolytic enzymes, oxygen free radicals Complication to lung tissue o Inflammatory mediators cause increased alveolar-capillary permeability (hallmark of ARDS)***** o
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  • Spring '14
  • Brinkley
  • Acute respiratory distress syndrome, pulmonary edema, Pulmonary contusion,  Labs

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