Gleevec.docx - Gleevec Questions and Answers Key Points...

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Gleevec: Questions and Answers Key Points What is Gleevec? Gleevec, also known as STI571, is a new drug that was approved by the the Food and Drug Administration for the treatment of chronic myeloid leukemia (CML), a cancer of white blood cells and for the treatment of a rare form of stomach cancer called gastrointestinal stromal tumor (GIST). (Question 1) Why is Gleevec different from most chemotherapy drugs? Gleevec represents a new class of cancer drugs and a new way of thinking about cancer. These molecularly targeted drugs are different because they target abnormal proteins that are fundamental to the cancer itself. (Question 2) What were the results of the previous clinical trials with Gleevec? In June 1998, the first clinical trial of Gleevec was launched. This small, initial study sought primarily to determine whether Gleevec is safe in people, not its effectiveness as a cancer drug. However, as the doctors gradually increased the dose of the drug, they noticed dramatic responses in their patients, all of whom were no longer benefitting from previous therapy. (Question 3) What is chronic myelogenous leukemia, or CML? CML affects the blasts that develop into multiple cell types in the bone marrow, including the white blood cells (granulocytes). The white blood cells do not mature normally and become too numerous. Immature white blood cells are then found in the blood and the bone marrow. (Question 4) What is GIST? A Gastrointestinal stromal tumor (GIST) is a type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant.
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  • Spring '14
  • Brinkley
  • Chemotherapy, Leukemia, Gastrointestinal stromal tumor, chronic myelogenous leukemia, imatinib, Gleevec

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