Intro to Genetics BIOS2500 Lecture 1 Chapter 2 Mendel’s...

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Intro to Genetics BIOS2500 Lecture 1 Chapter 2 Mendel’s 1st Law
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Don Kane PhD from U of Oregon (Eugene, Oregon) – studies genes that are necessary for early development in zebrafish Post doc w/ Christiane Nüsslein Volhard (Tübingen, Germany) – identified lots more genes that are necessary for early development in zebrafish In my lab, along with Rachel Warga and Tanya Petrachkova, we study genes that are necessary for early development in zebrafish We call ourselves developmental geneticists.
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Chapter 2 some terms Mendel’s 1st Law Meiosis some problems
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Single-gene inheritance patterns One of the first Qs to ask about a mutant is if it can be explained by a mutation in a single gene. So one of a geneticist’s first tools is to check if Mendel’s 1st law applies to a newly discovered mutant.
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some terms: gene discovery - looking for genes affecting some biological process based on finding mutants (or by genomics) crosses - deliberate matings mutant - a creature containing a mutation (usually has a mutant phenotype) wild type (or WT) - normal alleles or normal phenotype genetic dissection - using mutations to understand a given biological function
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Genetic analysis usually begins with mutants flower and leaf mutants. ag = agamous ap = apetala lfy = leafy
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zebrafish early arrest mutants .... turns out, all cell cycle mutants!
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fungi colony mutants.
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The seven phenotypic pairs studied by Mendel
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17 Learning about sex in plants
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Cross-pollination and selfing are two types of crosses
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some more terms: pure line - population with same homozygous genotype ...breeds “pure” P (parental generation) - initial cross of two pure lines. Sometimes, a cross with known genotypes (not pure) F1 (first filial generation) - progeny from P cross. F2 (second filial generation) - progeny from F1 incross. sometimes: F3 - progeny from F2 incross.
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  • Fall '08
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