Exam 2 and Key 2018.pdf - Fundamentals of Biochemistry...

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1 Fundamentals of Biochemistry Examination 2 for BCH401G Tue/Thur Section 002 Spring 2018 Please print your name on the automated scoring sheet and fill in the circles below each letter of your name Please place the letter for the answer that you select in the correct place on the automated scoring sheet. We will only grade the scoring sheet. Please use a pencil to fill in the automated scoring sheet Please note that there are five possible answers for every question and that the answers are in alphabetical order. You should not assume we have balanced the number of questions with A, B, C, D and E as answers Please answer all questions. There is no penalty for guessing. Except to correct typographical errors, faculty will not discuss exam questions during the exam Chapter 8 1. How does the neurotoxin, diisopropyl fluorophosphate (PF-3), inhibit the enzyme, acetylcholinesterase, that normally hydrolyzes the neurotransmitter, acetylcholine? (H 3 C) 2 HCO P OCH(CH 3 ) 2 F O PF-3 A. PF-3 forms a covalent bond with acetylcholine B. PF-3 reacts irreversibly with a serine in the active site of acetylcholinesterase C. PF-3 cleaves acetylcholinesterase on the carboxyl side of a serine in the active site D. PF-3 prevents the hydrolysis of an acetyl enzyme intermediate E. PF-3 is an allosteric inhibitor that binds acetylcholinesterase at a site other than the active site 2. Which of the following amino acids in a protein would be most prone to a reaction with an irreversible enzyme inhibitor? A. Ala B. Cys C. Ile D. Phe E. Val
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