Eukaryote Genome Organization

Eukaryote Genome Organization - Eukaryote Genome...

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Unformatted text preview: Eukaryote Genome Organization Genome size is significantly larger than prokaryotes larger number of genes 32,000 (human) vs 4300 (E. coli) large amount of noncoding DNA 3200 Mbp (human) vs 4.6 (E. coli) DNA binding to proteins to form chromatin Chromatin Structure v Multiple levels of chromatin structure v Based on successive levels of DNA packing v Dependent on different protein binding Nucleosome Binding Are responsible for the first level of DNA packing in chromatin Histones have lots of basic amino acids: bind tightly to DNA phosphate backbone Forms 10-nm fiber Proteins called histones arranged as nucleosomes 10-nm Fiber 2 nm 10 nm DNA double helix Histone tails His- tones Linker DNA (string) Nucleosome (bead) Histone H1 (a) Nucleosomes (10-nm fiber) Electron micrographs show: unfolded chromatin appears as "beads on a string" each bead is a nucleosome of 10-nm diameter 30-nm Chromatin Fiber...
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Eukaryote Genome Organization - Eukaryote Genome...

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