Cellular Respiration

Cellular Respiration - Cellular Respiration Catabolic...

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Cellular  Respiration Catabolic Process:   converting food to   ATP  and  NADH  energy  via  oxidation Occurs in mitochondria  with  O2 consumption   and  CO2 + H2O  production
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Different food sources converge into Glucose Metabolism THREE STAGES GLYCOLYSIS cytoplasm CITRIC ACID CYCLE mitochondrial matrix OXIDATIVE PHOSPHORYLATION mitochondrial inner membrane
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The Mitochondrion
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Overview of Glucose Metabolism Chemical bond energy converted to Electron Transfer Energy Two Means of ATP synthesis: Substrate-level & Oxidative
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ELECTRON TRANSFER v OXIDATION : Loss of e- v REDUCTION : Gain of e- Occurs together or Redox Couple H+ may or may not be transferred Dehydrogenase: Enzymes catalyzing e- + H+ transfers
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becomes oxidized (loses electron) becomes reduced (gains electron) Xe- + Y X + Ye- Reducing agent (donates electron) Oxidizing agent (accepts electron) ∆G < 0 (spontaneous) e- transfer from lower & higher affinity
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Oxidation-Reduction Reactions occur as a Redox Couple Electrons are transferred from lower to higher electron affinity High Free Energy Low Free Energy ∆G < 0
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NAD+ is an Electron Carrier NAD+ H O O O O– O O O– O O O P P CH2 CH2 HO OH H H HO OH HO H H N+ C NH2 H N H NH2 N N Nicotinamide (oxidized form) NH2 + 2[H] (from food) Dehydrogenase Reduction of NAD+ Oxidation of NADH 2 e– + 2 H+ 2 e– + H+ NADH O H H N C + Nicotinamide (reduced form) N low e- affinity Readily transfer electrons to molecules with higher e- affinity Dehydrogenase : enzymes catalyzing e- transfer with H+
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Respiration is a cumulative function of three metabolic stages Glycolysis (cytoplasm) The citric acid cycle (mitochondrial matrix) Oxidative phosphorylation (mitochondrial inner membrane) Stages of Cellular Respiration 09_16CellRespiration_A.swf
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Cellular Respiration - Cellular Respiration Catabolic...

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