10 CNMR 2D-NMR, and MRI

Organic Chemistry: Structure and Function

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1 13 C-NMR, 2D-NMR, and MRI Lecture Supplement: Take one handout from the stage
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2 Midterm Exam 2 Date: Monday May 21 Time: 5:00-6:50 PM Topics: All of spectroscopy (mass spectrometry today) Location: last name A-La in Haines 39 last name Le-Z in Moore 100 Calculators not allowed Question and Answer Session Lecture time, Monday May 21 Submit questions to [email protected] Label as “Question for Q&A” Deadline for possible inclusion: noon Sunday May 20 Extra Office Hours Saturday 3-5 PM, Young Hall 3077F (Steve Joiner) Sunday ???
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3 13 C-NMR Is NMR limited to 1 H? Any nucleus with I 0 can be observed I 0 when nucleus has odd number of protons or odd number of neutrons Includes 1 H, 2 H, 13 C, 19 F, 29 Si, 31 P, 127 I, etc. Examples 19 F: 9 protons, 10 neutrons; 100% natural abundance 31 P: 15 protons, 16 neutrons; 100% natural abundance } Easily observed by NMR Limited value for organic structure analysis -NMR rbon is backbone of organic molecules so 13 C-NMR has high potential, but... w natural abundance: 13 C = 1.1% ( 12 C = 98.9% but has 6 protons and 6 neutrons w probability that photon absorption causes spin flip: 1.6% compared to 1 H sult: 13 C spin flip much harder to observe than 1 H spin flip odern NMR spectrometers have overcome these problems; 13 C-NMR now routine
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4 13 C-NMR at can we deduce about molecular structure from 13 C-NMR spectrum? MR fundamentals are the same regardless of nucleus rmation from carbon NMR spectrum mber of signals: equivalent carbons and molecular symmetry emical shift: presence of high EN atoms or pi electron clouds egration: ratios of equivalent carbons upling: number of neighbors
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