Concept map 2.doc - Patho-physiology Patient Appearance The...

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Disease/Diagnosis: Lung Cancer Patho-physiology: The pathogenesis of lung cancer is like other  cancers, beginning with carcinogen-induced  initiation events, followed by a long period of  promotion and progression in a multistep  process.   Cigarette smoke both initiates and promotes carcinogenesis. The initiation event happens early  on, as evidenced by similar genetic mutations  between current and former smokers (e.g. 3p  deletion,   p53   mutations). Smoking thus causes a  “field effect” on the lung epithelium, providing a  large population of initiated cells and increasing the  chance of transformation. Continued smoke  exposure allows additional mutations to accumulate  due to promotion by chronic irritation and promoters in cigarette smoke (e.g. nicotine, phenol,  formaldehyde). The time delay between smoking  onset and cancer onset is typically long, requiring 
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  • Winter '18
  • dr wiley

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