Membranes and Transport.pdf - Membranes and Transport...

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Membranes and Transport Cystic Fibrosis CF is one of the most common genetic disease. It affects 4000 children born in USA. The patient lives aprx 40 yrs. CF is caused by a mutation in a single gene that codes for a protein so vital that a change in a particular amino acids has life altering consequences. Cells need to exchange molecules and ions constantly to maintain their internal environment. The plasma membrane (a thin layer of lipids and proteins that separates a cell from its surroundings) makes this happen. Some proteins are transportations proteins, so is CFTR (cystic fibrosis transmembrane conductance regulator), which is found in the plasma membrane of epithelial cells. Epithelial cells duct the lungs liver pancreases intestine skin. CFTR pump chloride ions out of those cells, and water follows the ions to produce this thin watery film over the epithelial tissues surface. This makes it possible for the mucus to slide easily over the tissue.
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  • Fall '16
  • CFTR

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