Bio82_17-18_FinalAnswers+RUBRIC.pdf

Bio82_17-18_FinalAnswers+RUBRIC.pdf - Final Exam 2017 Bio...

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1 Final Exam 2017 Bio 82 – Genetics ANSWERS + RUBRIC Name: __________________________________ SUNET ID: __________________________________ University ID: __________________________________ TA: __________________________________ I have neither given nor received aid during this exam: _________________________________ Instructions : This is a closed book exam. You have 3 hours to complete this exam. You may not use any other material than what is provided. You may use a calculator. At the completion of this exam, please sign the honor code statement above. Please write your answers within the lines or boxes provided. Answers should be brief. If incorrect information is included, points will be subtracted against correct information. The final pages of the exam contain punnett squares and additional scratch paper. We will not grade work done on these additional pages. Please be sure to put your final answers and the work you would like us to grade in the boxes within the questions.
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2 Score Tally Sheet for graders: Q1.________/12 Q2. _______/12 Q3.________/4 Q4.________/4 Q5.________/13 Q6.________/10 Q7.________/18 Q8.________/6 Q9.________/15 Q10._______/6 Total ______/100
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3 Question 1 (12 points) The following pedigree shows the pattern of inheritance of a rare familial form of cancer. Assume that the trait is being inherited in an autosomal dominant fashion in this family but shows incomplete penetrance . Also shown on the pedigree is the genotype of each individual for a particular VNTR marker. a) Identify each of the individuals who can unambiguously be identified as an example of Recombinant (R) or Non-Recombinant (NR) inheritance of the gene and VNTR marker. Write "R" or "NR" below the relevant individual/s in the pedigree above. b ) For the disease trait and the VNTR, determine the Max LOD score for this family. Show your work in the box and write your final answer on the line: The data gives an RF of 1/4. So the Max LOD score will be at RF 0.25 Log of odds ratio for RF 0.25= log of [ (0.75)^3 x (0.25)^1]/ (0.5^4) = +0.227 Max LOD Score:_ + 0.227 NR NR R NR
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4 Grading: 1a) 8 points +1 for each correctly identified individual. Includes students who identified individuals that they cannot unambiguously identify due to incomplete penetrance. (-4) 1b) 4 points • +2 for correct formula • +1 for correct theta • +1 for correct calculation • Full credit for solving correctly (0.454) if they solved NR=6 and R=2, and NR + R = 8.
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5 Question 2 (12 points) A geneticist is interested in determining the location of a recently discovered disease allele (called D). For this purpose, the geneticist has performed a study using affected and unaffected individuals. Shown below are the results obtained with two SNP markers (A and B) each of which has two alleles (A 1 vs. A 2 and B 1 vs. B 2 , respectively). 1% of chromosomes have the A 1 marker, the B 1 marker and the disease allele D 24% of chromosomes have the A 1 marker, the B 1 marker, but not the disease allele D 1% of chromosomes have the A 1 marker, the B 2 marker and the disease allele D 24% of chromosomes have the A 1 marker, the B 2 marker, but not the disease allele D 12% of chromosomes have the A 2 marker, the B 1 marker and the disease allele D 13% of chromosomes have the A 2 marker, the B 1 marker, but not the disease allele D 12% of chromosomes have the A 2 marker, the B 2
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