Bio821718MT1FinalAnswers+GradingRubric.pdf

Bio821718MT1FinalAnswers+GradingRubric.pdf - Midterm Exam...

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1 Midterm Exam 2017 Bio 82 – Genetics ANSWERS + GRADING RUBRIC Name: __________________________________ SUNET ID: __________________________________ University ID: __________________________________ TA: __________________________________ I have neither given nor received aid during this exam: _________________________________ Instructions : This is a closed book exam. You may not use any other material than what is provided. You may use a calculator. At the completion of this exam, please sign the honor code statement above. Please write your answers within the lines or boxes provided. Answers should be brief. If incorrect information is included, points will be subtracted against correct information. The final pages of the exam contain punnett squares and additional scratch paper. We will not grade work done on these additional pages. Please be sure to put your final answers and the work you would like us to grade in the boxes within the questions.
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2 Score Tally Sheet for graders: Think about point allocations Q1._________/7 Q2. ________/14 Q3.________/2 Q4.________/6 Q5.________/4 Q6.________/6 Q7.________/16 Q8.________/7 Q9.________/9 Q10._______/15 Q11._______/14 Total ______/100
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3 Question 1 (7 points) DNA polymerase makes a single mistake when copying DNA and puts an “A” in place of a “G” in the DNA strand it is newly synthesizing shown below (note we are only showing one strand here). Normal DNA 5’-TTTT G CCCC-3’ DNA with mistake 5’-TTTT A CCCC-3’ a) (2 pts) Which of the following was the sequence on the original DNA template strand the DNA polymerase was copying? 1) 5’-TTTT A CCCC-3’ Answer (1-4):___ 3 ____________ 2) 5’-TTTT G CCCC-3’ 3) 5’-GGGG C AAAA-3’ 4) 5’-GGGG T AAAA-3’ b) (2 pts) If this single mistake was made when the DNA was being replicated just before a cell went into meiosis (and it wasn’t repaired, resulting in an A/T pair at this site), how many of the 4 meiotic products (the gametes) would have the incorrect “A” version? 1 2 3 4 Circle correct number c) (3 pts) If this was in a male, and the gamete (sperm) with the incorrect “A” version fertilizes an egg whose DNA in this region reads 5’-TTTT G CCCC-3’, which of the following things can we say with reasonable certainty? (Circle ALL your answer(s)) 1) If we genotyped the zygote produced from this fertilization it would be heterozygous for “A” and “G”. 2) If the presence of the “A” instead of the “G” led to the production of a non-functional liver enzyme, when the zygote grew into a baby, it would have reduced liver function. 3) If we genotyped the baby’s blood and found that it was homozygous for “A” we would know that DNA polymerase made an error during replication in the baby. + 1 for circling 1, +1 for circling 3, + 1 for leaving 2 blank
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4 Question 2 (14 points) Foxes exhibit different coat colors based on which alleles of the Agouti gene they carry (yes, the same Agouti that influences mouse color). Phenotype genotype symbols SNP chip (microarray)readout Red fox A r A r “G” Silver fox a a blank (no signal) Blue fox A w A w “A” You cross the foxes and get (put answer on line): a) (2 pts) Blue X silver Blue fox _ A w a ______ (genotype) ___ "A" ____ SNP chip readout b) (2 pts) Red X silver Pink fox _ A r a ______ (genotype) ___ "G" ___ SNP chip readout c) (2 pts) Red X Blue Red fox _ A r A w ______ (genotype) _ "A" "G" _
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