Biomaterials - 1 MLE1101 BIOMATERIALS Prof SH Teoh...

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Unformatted text preview: 1 MLE1101 BIOMATERIALS Prof SH Teoh Department of Mechanical Engineering 9 Engineering Drive 1, Singapore 117576 Tel: 68744605, email:mpetsh@nus.edu.sg OVERVIEW 2 Video: Artificial Heart 3 BIOMATERIALS I. Biological Materials Basic constituents materials: collagen, elastin, keratin, chitin and cellulose. Complex/Composite tissues : bone, cartilage, tendons, arteries, skin and dentin II. Synthetic Biomedical Materials Polymeric: UHMWPE, PMMA, PEEK, PS, PA, Silicone, PU, PTFE, PCL, PET, PLLA Metallic: Stainless Steel, Cobalt Base Alloy, Titanium & Alloy, Gold, Platinum Ceramic: A1 2 O 3 , Zirconia [ZrO 2 ], Carbon, Hydroxylapatite [Ca 10 (PO 4 ) 6 (OH) 2 ], Tricalcium Phosphate [Ca 3 (PO 4 ) 2 ], Bioglass [Na 2 O(CaO)(P 2 O 3 )(SiO 2 )], Calcium Aluminate [Ca(A1 2 O 4 )] Composite: Carbon Fibre(CF)/PEEK, CF/UHMWPE, CF/PMMA, Silica/BIS-GMA,PET/Collagen, Zirconia/Silica/BIS-GMA Classified into 1) Soft Tissue, 2) Hard Tissue 4 REQUIREMENTS Biomaterials must have special properties, for example, biocompatibility, biodegradability, non-carcinogenic, corrosion resistant, good tissue adhesion and low toxicity. Numerous examples can be cited to show the application areas of biomaterials, such as in the artificial heart, plastic hand, contact lenses, hip joint replacement, artificial ligament, intravenous devices and in kidney dialysis equipment. 1. Biocompatibility : The materials must not disturb or induce un-welcoming response from the host 2. Manufacturability The materials must be easily fabricated into shape that are functional 3. Sterilizability : The materials must be able to undergo sterilisation. Ref: Schoen et al: Pathological considerations in replacement cardiac valves, CVP, 1992:29-32 5 Applications of Biomaterials Artificial Ear - Silicone Rubber Artificial Eye - Hydroxyapatite Contact Lens - PMMA Bone Plate - Stainless Steel Acetabular Cup - UHMWPE Heart Valve Housing -Ti, Stellite Disc - Pyrolytic Carbon, Delrin Sewing Ring - Dacron (PET) Cosmetic Hand Silicone Rubber Ear Implant Vascular Grafts - Teflon (PTFE), Gore- Tex Artificial Limb - Polypropylene CFRP Joint Prosthesis - Stainless Steel, Cobalt Base Alloys, Titanium Alloys 6 12 10 1 300 40 40 40 50 100 150 200 250 300 350 ELONGATION (%) P o l y m e r s S o f...
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Biomaterials - 1 MLE1101 BIOMATERIALS Prof SH Teoh...

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