Adult Nursing III - SEPTIC - EXAM 2.docx - SEPTIC...

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SEPTIC Pathophysiology: i. 10 th leading cause of death in U.S. ii. Sepsis: life threatening organ dysfunction caused by a deregulated host response to infection iii. Pathophysiology 1. Invasion by a pathogen activates the immune system mobilization of macrophages and neutrophils activation of pro-inflammatory cytokines activation of proteins that immobilize and breakdown pathogens activation of the coagulation system (fibrin mesh helps localize the invader) vessels dilate and the capillary permeability increases causing local redness , edema, and warmth; sepsis occurs when the inflammatory response is no longer localized cytokines stimulate release of tissue factor (TF) TF initiates the clotting cascade which causes… a. Widespread microvascular thrombosis b. Anti-clotting mechanisms are impaired c. Host uses up all of its clotting factors and goes into DIC iv. Risk Factors 1. Intrinsic a. Extremes of age b. Coexisting diseases c. Malnutrition 2. Extrinsic a. Invasive devices b.
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  • Fall '18
  • c. Fluid therapy

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