Pharmacology III- Chapter 25 - Anti-imflammatory Drugs.rtf - Chapter 25 Antiinflammatory Drugs Pharmacology III \u2013 Study Guide \u2013 EXAM 4 MULTIPLE

Pharmacology III- Chapter 25 - Anti-imflammatory Drugs.rtf...

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Chapter 25: Antiinflammatory DrugsPharmacology III – Study Guide – EXAM 4MULTIPLE CHOICE1.A nursing student asks the nurse to explain the role of cyclooxygenase-2 (COX-2) and its role in inflammation. The nurse will explain that COX-2a.converts arachidonic acid into a chemical mediator for inflammation.b.directly causes vasodilation and increased capillary permeability.c.irritates the gastric mucosa to cause gastrointestinal upset.d.releases prostaglandins, which cause inflammation and pain in tissues.ANS: ACOX-2 is an enzyme that converts arachidonic acid into prostaglandins and their products, and this synthesis causes pain and inflammation. They do not act directly to cause inflammation. COX-1 irritates the gastric mucosa. COX-2 synthesizes but does not release prostaglandins. Page 3372.A nursing student asks how nonsteroidal anti-inflammatory drugs (NSAIDs) work to suppress inflammation and reduce pain. The nurse will explain that NSAIDsNSAIDs act by inhibiting COX-1 and COX-2 to help block prostaglandin synthesis. They do not have direct action on tissues, nor do they interfere with chemical receptor sites or neuronalpathways. Page 3373.A patient is taking ibuprofen 400 mg every 4 hours to treat moderate arthritis pain and reports that it is less effective than before. What action will the nurse take?The patient should discuss another NSAID with the provider if tolerance has developed to the over-the-counter NSAID. Patients should not take aspirin with NSAIDs because of the increased risk of bleeding and gastrointestinal upset. Steroids are not the drugs of choice for arthritis because of their side effects and are not used unless inflammation is severe. A prescription NSAID would be used prior to starting corticosteroids. Increasing the dose will increase side effects but may not increase desired effects. The maximum dose per day is 2400 mg, which would most likely be exceeded when increasing the dose to 800 mg every 4 hours.Page 337
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