BS111-Lecture 13 - 1 6C 2C O2 absent 6C 2C 2 I Oxidative...

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2 O 2 absent 6C 6C 2C 2C
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3 I. Oxidative Phosphorylation A. Electron transport chain B. Chemiosmosis Structure of the mitochondrion
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4 Why does the electron transport chain have so many steps? Why not in one step? O H NAD O H NADH 2 2 2 1 + + + + + A. Electron transport “chain” Maximizes work with less loss to heat
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5 Pyuvate TCA Cycle Not a protein
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6 Complex I NADH-Q reductase Depending on the organism: contains 14 to 50 subunits. NADH other cofactors in enzyme QH 2 Two electrons/NADH + H+
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7 Complex II Succinate Dehydrogenase (also in TCA cycle). Contains 5 subunits. FADH 2 other cofactors in enzyme QH 2 – Two electrons/FADH 2
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8 Flavin adenine dinucleotide
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9 Complex III Cytochrome c reductase Contains 11 subunits Uses multiple cofactors to Oxidize QH 2 Enzyme passes 2 electrons onto 2 Cytochrome C (peripherally bound).
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10 Complex IV Cytochrome c oxidase Contains 4 to 13 subunits Uses multiple metals and cofactors to reduce molecular oxygen (the final acceptor) to water.
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11 Summary so far.
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