BS111-lecture 25 - *Jessica Miller*Brett Diffin*Yelena...

Info icon This preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
1 * Jessica Miller * Brett Diffin * Yelena Kleshchik * Laura Van Putten ** * Dina Valeeva ** * Jennifer Vanvleet * Young Woo On * Audrey Karogosian * Nicole Butler * Rachel Young * Robert Vinney * Peter Wilson * Andrew Robertson * Bradley Gauthier * Ryan Burke * Yelnea Kleshchik * Jerin Guindon Dec 13 th Thursday 322 chemistry 10:00-noon
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 I. Processing Eukaryotic mRNA genetic transcripts. 1. Ends—processed 2. Introns--excised Although we are emphasizing this type of transcription remember genes also code for rRNA and tRNA
Image of page 2
3 G-cap added at the 5′ end (modified guanosine triphosphate)— Modified GTP molecule is attached to facilitate ribosomal (translation) binding. Protects it from being digested by ribonucleases . Different lengths of poly-adentlyation give different lifetimes? Also, might be important for exporting mRNA out of nucleus? Signal for cutting off tail Enzyme adds
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
4 That in addition to modifying the mRNA ends, extra DNA in genes (introns) have to be removed CAP Poly-A tail Pre-mRNA is bound by small nuclear ribonucleoprotein particles ( snRNPs ).
Image of page 4
5 The mechanism for this “splcing”: Poly-A tail CAP Consensus sequences are short sequences between exons and introns. snRNP (RNA) binds here, and also near the 3′ end of the intron. lariat formation and degradation of DNA introns.
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
6 II. Regulating Gene Expression Expression of genes (i.e. from pre-mRNA to translation) must be precisely regulated during development.
Image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern