BS111-lecture 25 - *Jessica Miller *Brett Diffin *Yelena...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
1 * Jessica Miller * Brett Diffin * Yelena Kleshchik * Laura Van Putten ** * Dina Valeeva ** * Jennifer Vanvleet * Young Woo On * Audrey Karogosian * Nicole Butler * Rachel Young * Robert Vinney * Peter Wilson * Andrew Robertson * Bradley Gauthier * Ryan Burke * Yelnea Kleshchik * Jerin Guindon Dec 13 th Thursday 322 chemistry 10:00-noon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 I. Processing Eukaryotic mRNA genetic transcripts. 1. Ends—processed 2. Introns--excised Although we are emphasizing this type of transcription remember genes also code for rRNA and tRNA
Background image of page 2
3 G-cap added at the 5′ end (modified guanosine triphosphate)— Modified GTP molecule is attached to facilitate ribosomal (translation) binding. Protects it from being digested by ribonucleases . Different lengths of poly-adentlyation give different lifetimes? Also, might be important for exporting mRNA out of nucleus? Signal for cutting off tail Enzyme adds
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 That in addition to modifying the mRNA ends, extra DNA in genes (introns) have to be removed CAP Poly-A tail Pre-mRNA is bound by small nuclear ribonucleoprotein particles ( snRNPs ).
Background image of page 4
5 The mechanism for this “splcing”: Poly-A tail CAP Consensus sequences are short sequences between exons and introns. snRNP (RNA) binds here, and also near the 3′ end of the intron. lariat formation and degradation of DNA introns.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 II. Regulating Gene Expression Expression of genes (i.e. from pre-mRNA to translation) must be precisely regulated during development.
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 27

BS111-lecture 25 - *Jessica Miller *Brett Diffin *Yelena...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online