BS111-lecture 26 - 1 Chapter 15 Cell Signaling and...

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2 Cell Signaling and Communication Chapter 15
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3 All cells process information from the environment. The information can be a physical stimulus, such as light; or chemical. Signals (information) can come from outside the organism, or from neighboring cells. I. Cell Signals and their response To respond to a signal, a cell must have a specific receptor by specific transcription that can detect it. A specific signal transduction pathway is the series of steps involved in a cell’s response to a signal.
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4 In a large multicellular organism, signals reach target cells by diffusion or by circulation in the blood. Autocrine signals affect the cells that made them. Paracrine signals affect nearby cells. Diffusion A. Signals
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5 Hormone signals reach target cells by circulation in the blood. . Endocrine signally Circulation
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6 A. Signal Transduction A signal transduction pathway is the series of steps involved in a cell’s response to a signal.
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7 External environment Cell wall Plasma membrane Outer membrane Intermembrane space Pores Solute (signal) Solutes enter the space between the two membranes through large pores in the outer membrane of E. coli. The EnvZ receptor protein changes shape in response to the high solute concentration, catalyzing the addition of a phosphate from ATP. The phosphate from EnvZ is
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This note was uploaded on 03/29/2008 for the course BS 111 taught by Professor Patterson during the Spring '05 term at Michigan State University.

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BS111-lecture 26 - 1 Chapter 15 Cell Signaling and...

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