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Unformatted text preview: Lipids in Chronic Disease (CHD & CA): Study Questions Synopsis : This lecture addresses the role ō lipids in chronic disease; specifically with regard to Coronary Heart Disease (CHD). First, we'll study the incidence, pathology & etiology ō CHD. Next, the impact ō lipid levels & their associated risk as well as diet & serum lipids will be explored. Practical, actionable diet recommendations conclude the topic. Synopsis : This lecture examines what we know about the role ō lipids in the development ō cancer. On this issue we explore areas ō scientific consensus as well as disagreement. Concluding the lecture are specific diets (American, Asian & Mediterranean) & their correlation to cancer incidence. Textbook readings : Chapter 5 Coronary Heart Disease (CHD) I. Incidence a. Leading cause ō death in US b. Half ō CHD deaths at >65yr c. Began to increase ~ 1920 d. Peaked at 328 per 100,000 in 1965 e. 236 per 100,000 in 1983 Incidence What is the second major cause ō death in the US (after cancer)? Coronary Heart Disease (CHD) : disease caused by atherosclerosis that results in narrowing & thickening ō arterial walls leading to insufficient blood flow to heart muscle & possibly resulting in heart attack After cancer, heart disease (CHD) is the 2 nd major cause ō death in US. Is CHD a disease ō older or younger people? CHD is a disease ō older people.- 50% : > 65 yrs (common) What are the trends in CHD? Is it increasing or decreasing? Trends in CHD :- Increased around 1920 or so (end ō WWI)- Peaked in 1965 at 328 deaths/100,000 pop.- Dropped to 236 deaths in 1983- Decline at slower rate ( decreasing ) due to better (ER) & more treatment, prevention, & less smoking II. Pathology [Artherosclerosis ] a. Thickening & narrowing ō arterial walls b. Plaques - invasion ō cholesterol into intima c. Diminishes circulation or blocked by clot d. Clot formed by hemorrhage ō plaque or elsewhere [Road to a heart attack ] e. Ischemia cases MI or stroke (cerebrovascular accident) f. Begins at early age Pathology : study ō disease processes Atherosclerosis What is atherosclerosis? What happens to artery walls? atherosclerosis : thickening & narrowing ō artery walls caused by cholesterol invasion ⇒ plaque formation- process by w/c cholesterol is deposited in arterial plaques, gradually thickening artery walls & narrowing arterial passage- process by w/c cholesterol from LDL is deposited in arterial walls, resulting in thicker wall & narrower passage for blood- High levels ō LDL cholesterol contribute to atherosclerosis. What are plaques? What are they formed ō? Where do they occur? Plaques are invasion ō cholesterol into arterial walls . What do plaques do to circulation? What happens when plaques & blood clots interact? Where are these clots formed?...
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- Spring '08
- Nutrition, Atherosclerosis