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Unformatted text preview: Lipids in Chronic Disease (CHD & CA): Study Questions Synopsis : This lecture addresses the role lipids in chronic disease; specifically with regard to Coronary Heart Disease (CHD). First, we'll study the incidence, pathology & etiology CHD. Next, the impact lipid levels & their associated risk as well as diet & serum lipids will be explored. Practical, actionable diet recommendations conclude the topic. Synopsis : This lecture examines what we know about the role lipids in the development cancer. On this issue we explore areas scientific consensus as well as disagreement. Concluding the lecture are specific diets (American, Asian & Mediterranean) & their correlation to cancer incidence. Textbook readings : Chapter 5 Coronary Heart Disease (CHD) I. Incidence a. Leading cause death in US b. Half CHD deaths at >65yr c. Began to increase ~ 1920 d. Peaked at 328 per 100,000 in 1965 e. 236 per 100,000 in 1983 Incidence What is the second major cause death in the US (after cancer)? Coronary Heart Disease (CHD) : disease caused by atherosclerosis that results in narrowing & thickening arterial walls leading to insufficient blood flow to heart muscle & possibly resulting in heart attack After cancer, heart disease (CHD) is the 2 nd major cause death in US. Is CHD a disease older or younger people? CHD is a disease older people.- 50% : > 65 yrs (common) What are the trends in CHD? Is it increasing or decreasing? Trends in CHD :- Increased around 1920 or so (end WWI)- Peaked in 1965 at 328 deaths/100,000 pop.- Dropped to 236 deaths in 1983- Decline at slower rate ( decreasing ) due to better (ER) & more treatment, prevention, & less smoking II. Pathology [Artherosclerosis ] a. Thickening & narrowing arterial walls b. Plaques - invasion cholesterol into intima c. Diminishes circulation or blocked by clot d. Clot formed by hemorrhage plaque or elsewhere [Road to a heart attack ] e. Ischemia cases MI or stroke (cerebrovascular accident) f. Begins at early age Pathology : study disease processes Atherosclerosis What is atherosclerosis? What happens to artery walls? atherosclerosis : thickening & narrowing artery walls caused by cholesterol invasion plaque formation- process by w/c cholesterol is deposited in arterial plaques, gradually thickening artery walls & narrowing arterial passage- process by w/c cholesterol from LDL is deposited in arterial walls, resulting in thicker wall & narrower passage for blood- High levels LDL cholesterol contribute to atherosclerosis. What are plaques? What are they formed ? Where do they occur? Plaques are invasion cholesterol into arterial walls . What do plaques do to circulation? What happens when plaques & blood clots interact? Where are these clots formed?...
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This note was uploaded on 03/29/2008 for the course NUTRI SCI 132 taught by Professor Anderson during the Spring '08 term at Wisconsin.
- Spring '08