Student name: Elizabeth RobinsonBrand/trade name: Sitavig. Xerese, ZoviraxClassification: AntiviralsAction: Interferes with viral DNA synthesis.Adult dose: 200 mg q 4 hr while awake for 7-10 days or 400 mg q 8 hr for 7-10 days Peds dose: 80 mg/kg/day in 2-5 divided dosesAdverse effects: CNS:Seizures, dizziness, headache, hallucinations, trembling. GI:diarrhea, nausea, vomiting, increase liver enzymes, hyperbilirubinemia, abdominal pain, anorexia.GU:Renal failure, crystalluria, hematuria, renal pain. Derm: Steve- Johnson syndrome, acne, hives, rash, unusual sweating. Endo:changes in menstrual cycle. Hemat: Thrombotic thrombocytopenic purpura/ hemolytic uremic syndromeLocal:pain, phlebitis, local irritation. MS:joint pain. Misc:polydipsia.Drug interactions:Drug-Drug: Probenecid increased blood levels of acyclovir. Increased blood levels and risk of toxicity from theophylline; dose adjustment maybe necessary. Decreased blood levels and may decrease effectiveness of valproic acid or phenytoin. Concurrent use of other nephrotoxic drugs increases risk of
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- Fall '19
- Nephrology, Herpes zoster, valaciclovir