This preview has intentionally blurred sections. Sign up to view the full version.
View Full Document
Unformatted text preview: histones 1.65 x 10 6 (nucleosomes) x 8 histones = 1.32 x 10 7 / 4 (4 histone proteins involved ) = 3.3 x 10 6 molecules of each histone (H2a, H2b, H3 and H4). 9.34 3 x 10 9 nucleotide pairs per genome (bp/genome) Average nucleotide pair MW = 660 g/mol So MW of haploid human genome = 3 x 10 9 x 660 g/mol = 1.98 x 10 12 AVOGANDRO’S #: Note: one Mole of any substance contains 6.02 x 10 23 molecules/mole 6.02 x 10 23 (genome copies or ”molecules”) / 1.98 x 10 12 (grams of genome) = 3.04 x 10 11 (genome copies per gram) So since 10 6 μg = 1g there are 3.04 x 10 5 copies of genome per μg Or since 10 3 mg = 1g there are 3.04 x 10 8 copies of genome per mg ** The question asks for copies per mg, so I am not sure why the solutions manual gives the answer in copies per μg. I figured this might be confusing so I included the answer in both forms....
View
Full Document
 Spring '08
 Larkin
 Genetics, DNA, Human genome, Base pair, nucleotide pairs

Click to edit the document details