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Genet+Chapters+5+and+6 - Ch 5 Opening In 1910 T H Morgan...

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Ch. 5 Opening: In 1910, T. H. Morgan discovered a white-eyed mutation with unusual “sex-linked” inheritance
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T.H. Morgan, Drosophila , and Sex- linkage T.H. Morgan started genetic studies with fruit flies ( Drosophila melanogaster ), 1909- 1930s. Made many discoveries, but the first was discovery of sex-linkage. Sex linkage of white-eyed mutant ( w ) was important proof that genes were on chromosomes.
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Fig. 5.2 Human Sex Chromosomes Differ in size and morphology Terminal regions similar, but few genes in common. Y has few genes, X many genes X and Y pair and disjoin in meiosis as if they were homologous chromosomes
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More on sex chromosomes Many organisms have sex chromosomes like X and Y. Chromosomes other than sex chr.= autosomes . XY males are said to be hemizygous , have only one copy of X chr. genes. XY males always show phenotype of recessive alleles of X chr. genes.
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Morgan’s observation: Crossed red-eyed female to white-eyed male. F1 all red eyes. F2 all females red eyes, males 1/2 red and 1/2 white.
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Fig. 5.3 Morgan’s hypothesis diagramed w is on X chr.
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