Discussion week 1 response 1.docx - Normal age-related changes could alter the drug pharmacokinetics which can cause unwanted adverse effects(Arcangelo

Discussion week 1 response 1.docx - Normal age-related...

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Normal age-related changes could alter the drug pharmacokinetics, which can cause unwanted adverse effects (Arcangelo, Peterson, Wilbur, & Reinhold, 2017). The age-related changes cause decreased organ function in the liver and kidneys, alterations in fat composition in the body, and increased absorption and delayed gastric emptying (Arcangelo et al., 2017). Renal toxicity can manifest from decreased glomerular filtration rate (GFR) and reduced size of the kidneys (Arcangelo et al., 2017). Every year over the age of forty years, the GFR decreases by 1%, which affects drug excretion and metabolism (Arcangelo et al., 2017). Due to these factors, it is important to include completing blood labwork in the individualized care plan. Including a comprehensive metabolic panel (CMP) will provide information on the liver and kidney function. As you stated, benzodiazepines have less adverse effects on young and middle age adults.
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