BS110 Lecture 8 - Monday Feb 4, 2008 Amber Peters What...

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Monday Feb 4, 2008 Amber Peters
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What happens when meiosis goes awry? Too many chromosomes…or too few chromosomes Often can be lethal Monosomy, trisomy
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Non-disjunction during meiosis results in monosomy or trisomy Remember, this is just for 1 chromosomes and humans have 23 homologous pairs, 46 total
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Trisomy 21…Down’s Syndrome
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Down’s syndrome Most cases arise from non disjunction in the first meiotic division Incidents increases with increasing age of mother The father contributes the extra chromosome in about 15% of cases.
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Non-disjunction in Sex Chromosomes Klinefelter's syndrome , or XXY syndrome Extra X chromosome Small testicles and reduced fertility, behavioral changes 1 in 1000 males Turner syndrome Only one X chromosomes 1 out of every 2500-5000 females female sexual characteristics are present but generally underdeveloped
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Heterozygous advantages
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BS110 Lecture 8 - Monday Feb 4, 2008 Amber Peters What...

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