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Unformatted text preview: C HAPTER HAPTER ## ## M M ARIJUANA ARIJUANA Cannabinoid family o Cannabis sativa- leaves & _______ 80 identified cannabinoids - stalks been actively used for clothes, ropes, shoes, boxes, etc. for thousands of years plant grows anywhere o Delta-9-tetrahydrocannabinol ( _____ )- major psychoactive cannabinoid- identified & isolated in _____ Drug of its own class o Mixture of effects: 1. ________ with no risk of breath suppression or dying 2. ________ but not enough to be called a stimulant 3. ________ at high doses but structure does not resemble LCD or any other hallucinogens 4. ________ (1) effects are mild (2) pharmacologically not related to opiates or opiate-like drugs Marijuana history o Antimarijuana campaign o Two major factors- failure of the ________- prejudice against ________ ________ o Marijuana dangers highly publicized- a killer weed - movies and commercials Reefer Madness Marijuana: Weeds with roots in hell o The Marijuana Tax Act ( ___ ) o 1942 removed from ________ o Two major theories- introduced to support the campaign Pharmacological violence theory Gateway theory o 1970 Schedule ________ o Today - still classified as a schedule I drug - getaway theory is still popular Pharmacokinetics o Administration inhalation or ingestion average joint: ________ of THC; 5 -10 mg absorbed behavioral effects - start ________ after smoking begins- last no longer than 2-3 hours o Distribution: ________ to all organs (fatty) more concentration of THC in the organs with significant concentrations of fat easily crosses ________ & ________ o Metabolism slow Half-life 30 hrs - chronic smokers accumulate THC intensified & prolonged effects of the subsequently smoked marijuana- a ________ ________ Pharmacodynamics o Cannabinoid receptors o ________ (1) found mostly in the brain: the amygdala, basal ganglia, brain stem, cerebellum, cerebral cortex, hippocampus, hypothalamus, nucleus accumbens, and spinal cord (2) associated with behavioral & cognitive effects of marijuana o ________ o found mostly outside of the brain (2) responsible for the immune effects Acute physiological effects o (Relatively minor) 1. ________ heart beat 2. Thirst 3. ________ appetite 4. ________ responsiveness - differ depending on the culture - recent studies: males differential response depending on the dose Acute psychological effects o Euphoria & well-being o Dreaminess o ________ impairment o ________ alterations- sharpened sense of sight & sound- increased awareness of surroundings- may find trivial events funny - hallucinations with the higher doses o ________ changes- feeling that became more creative- feeling of time slowing down o Significant deficits in behavior ________ impairment Reaction stays the same but ability to attend to ________ signals with chronic & heavy use impairments in sensory-motor performance & memory persist well beyond subjective feelings of intoxication Chronic effects o Withdrawal Onset - 48 hours...
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This note was uploaded on 03/30/2008 for the course PSYCH 315 taught by Professor Armstrong during the Spring '08 term at Iowa State.

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