Chapter08.pptx - Introduction to Clinical Pharmacology Chapter 8 Antibacterial Drugs That Interfere With Protein Synthesis Copyright \u00a9 2014 Wolters

Chapter08.pptx - Introduction to Clinical Pharmacology...

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Introduction to Clinical Pharmacology Chapter 8 Antibacterial Drugs That Interfere With Protein Synthesis Introduction to Clinical Pharmacology Chapter 8 Antibacterial Drugs That Interfere With Protein Synthesis
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Tetracyclines Tetracyclines Anti-infectives composed of natural and semisynthetic compounds Actions: inhibit bacterial protein synthesis Used as broad-spectrum antibiotic when penicillin is contraindicated Treat the following infections: Rickettsial diseases; intestinal amebiasis; skin and soft tissue infections; uncomplicated urethral, endocervical, or rectal infections; adjunctive treatment; and infection with Helicobacter pylori
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Tetracyclines: Adverse Reactions Tetracyclines: Adverse Reactions Gastrointestinal/other body system reactions: o Nausea and/or vomiting o Diarrhea o Epigastric distress o Stomatitis o Sore throat o Skin rashes o Photosensitivity reaction
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Tetracyclines: Contraindications Tetracyclines: Contraindications Contraindicated in patients: o With hypersensitivity; during pregnancy, lactation; children younger than 9 years Nursing alert: o Not given to children younger than 9 years of age o Prolonged therapy: Bacterial/fungal overgrowth of nonsusceptible organisms
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Tetracyclines: Precautions Tetracyclines: Precautions Used cautiously in patients with: o Impaired renal function o Liver impairment Chronic care alert: o May reduce insulin requirements in patients with diabetes. Blood glucose levels should be monitored frequently.
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Tetracyclines: Interactions #1 Tetracyclines: Interactions #1 Interacting drug Effect of interaction Antacids containing aluminum, zinc, magnesium, or bismuth salts Decreases effectiveness of tetracyclines Oral anticoagulants Increases risk for bleeding Oral contraceptives Decreases effectiveness of contraceptive agent
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Tetracyclines: Interactions #2 Interacting drug Effect of interaction Digoxin Increases the risk for digitalis toxicity Calcium-rich foods Causes potentially impaired absorption of tetracycline
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Aminoglycosides: Actions and Uses Aminoglycosides: Actions and Uses Blocks step in protein synthesis necessary for bacterial multiplication Used against gram-negative microorganisms Bowel preparation Hepatic coma
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Aminoglycosides: Adverse Reactions Aminoglycosides: Adverse Reactions Nausea Vomiting Anorexia Rash Urticaria Nephrotoxicity (damage to the kidneys by a toxic substance) Ototoxicity (damage to the hearing organs by a toxic substance) Neurotoxicity (damage to the nervous system by a toxic substance)
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