NURS6501-Wk2.docx - Genetics also plays an important role in both disorders For people affected with OA inherited microRNAs may be responsible for

NURS6501-Wk2.docx - Genetics also plays an important role...

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Genetics also plays an important role in both disorders. For people affected with OA, inherited microRNAs may be responsible for mutations in the chondrocytes (Huether & McCance, 2017). It has also been observed that family members of affected patients tend to have OA disorder too (CDC, 2017a). Inherited human leukocyte antigen (HLA) can account for the presence and severity of RA disorder (CDC, 2017b). However, a manifestation of the disorder “is likely a combination of genetic factors interacting with inflammatory mediators” (Huether & McCance, 2017). Brittany White, Thank you for your informative post Brittany. As discussed in you post osteoarthritis and rheumatoid arthritis are disorders in which there is no cure and the individuals joints are affected. Pain control is a large factor geared towards managing the disease. As discussed, genetics play and important role, so individuals family members with OA and RA, especially younger generation need to be aware of life style choices that contributed to the genetic factor. Taking the steps to manage their health positively and build in life skills to contribute to quality of life later on, such as routine exercise and proper dietary and nutrition supplements. Van Steenbergen, Tsonaka, Huizinga, Cessie, and Van der Helm van Mil (2015) discussed findings from a study completed on 426 patients with RA who complete yearly radiologic follow-ups, measuring through progression in Sharp-van Heijde score (SHS) over a six year time frame. The assessment measured continuous outcome categories for no to little change, moderate or severe progression; recently identifying new genetic risk factors for radiologic progression to see if factors (Van Steenbergen, et al. 2015). From the studies based on the Icelandic population with RA, there was an estimation for the heritability of radiologic progression at 45% to 58%, with all genetic severity factors together explaining 12% to 18% of the variance in radiologic progression (Van Steenbergen, et al. 2015). Concluding that there is still research needed as relevant generic variants may still be unidentified or gene-gene interactions may play a role and that the predictive performance model is insufficient for use in clinical practice. . References Van Steenbergen, H., Tsonaka, R., Huizinga, T., Cessie, S., & Van der Helm van Mil, A. (2015).). Predicting the severity of joint damage in rheumatoid arthritis; the contribution of genetic factors. Annals of the Rheumatic Diseases, (5), 876. - org.ezp.waldenulibrary.org/10.1136/annrheumdis-2013-204277
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Luke Fontaine, I enjoyed your informative post discussing psoriasis and systemic lupus erythematosus (SLE) concepts of pathophysiology with differing maladaptive and physiological responses. I be focusing on ways that individuals with SLE are commonly treated for the chronic inflammatory injuries to tissues and subsequent joints. Currently, SLE is without a cure, treatment approaches include a plan with the use of conventional medicine typically with corticosteroids, non-anti-
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