MCB Exam 1 Notes 2/11 - Passive Transport 1 ● Multi pass...

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Passive Transport 1: Multi pass transmembrane proteins form a pore Net direction flows down an electrochemical concentration gradient Could an ion move passively against chemical gradient? Yes, because the charges on each side of the membrane could influence passive movement against a concentration gradient. Channels can be ion specific, only allow for one type of ion to pass (ie. only K or Ca) Movement is very fast b/c there is not binding interactions b/w membrane and ion Can be regulated→ gating allows for channel to be open or closed Gating: Voltage gated Voltage gated K+ channel: Tetramer made of 4 subunits (quaternary structure) with multiple membrane spanning domains N and C are both intracellular Where the subunits meet, they form a channel through the membrane Open through membrane depolarization Selective for ONLY K+ X ray crystallography, under right conditions you can get the sample to crystallize
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  • Fall '09

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