cancer genetics.pdf - Lecture 21 Cancer Genetics I Stephen...

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1 Lecture 21 Cancer Genetics I Stephen B. Gruber, MD, PhD November 18, 2002 “Cancer is, in essence, a genetic disease. Although cancer is complex, and environmental and other nongenetic factors clearly play a role in many stages of the neoplastic process, the tremendous progress made in understanding tumorigenesis in large part is owing to the discovery of the genes, that when mutated, lead to cancer.” Bert Vogelstein (1988) NEJM 1988; 319:525-532.
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