case study 5 part II .docx - Kentzel 1 Willow Kentzel Dr...

This preview shows page 1 - 2 out of 2 pages.

Kentzel 1 Willow Kentzel Dr. Kevin Lee BIO 453 February 25, 2019 Case Study 5 Part II 1. The APP genes main function is to provide instructions for the process of creating proteins called amyloid precursor protein. These proteins can be found in many tissues and organs throughout the human body, including the central nervous system, more specifically, the brain and spinal cord. There are more than fifty different mutations that can occur in the APP gene that can be one if the direct causes of EOFAD. These specific mutations are linked to less than ten percent of all EOFAD cases. The most prevalent APP mutation is responsible for altering one of the amino acids in the amyloid precursor protein. More specifically, the mutation switches the amino acid valine to the amino acid isoleucine at protein position 717. The issues in the brain arise from the higher amount of the amyloid B peptide and or from the creation of shape and texture form of the peptide. Once they are released from the cell, they can form amyloid plaques. A main characteristic of Alzheimer disease are these exact plaques that can eventually lead to the neurons in the brain dying.
Image of page 1

Subscribe to view the full document.

Image of page 2

{[ snackBarMessage ]}

Get FREE access by uploading your study materials

Upload your study materials now and get free access to over 25 million documents.

Upload now for FREE access Or pay now for instant access
Christopher Reinemann
"Before using Course Hero my grade was at 78%. By the end of the semester my grade was at 90%. I could not have done it without all the class material I found."
— Christopher R., University of Rhode Island '15, Course Hero Intern

Ask a question for free

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern