3 malit.presentation.pptx - Angiotensin IIreceptor blockers...

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Angiotensin II-receptor blockersAngiotensin II receptor blockers (ARBs) aremedications that block the action ofangiotensin II by preventing angiotensin IIfrom binding to angiotensin II receptors onthe muscles surrounding blood vessels.
ANGIOTENSIN II-RECEPTOR BLOCKER DRUGSAzilsartanCandesartanEprosartanIrbesartanLosartanOlmesartanTelmisartanValsartan
Therapeutic actions and indicationsThe ARBs selectively bind with the angiotensin II-receptor in vascular smooth muscle and in theadrenal cortex to block vasocontriction and therelease of aldosteroneThese action block the blood pressure- raisingeffects of the renin-angiotensin system and lowerblood pressureThey are indicated to be used alone or incombination therapy for the tratment ofhypertension and for the tratment of heart failurein the paitent who are intolerant to ACE inhibitors.
PharmacokineticsThese agent s are all given orallyThey are well absorbed and undergometabolism in the liver by cytochrome P450system.They excreted in feces and urineIt is not know whether they enter breast milkduring lactation
ContraindicationsThe ARBs are contraindicated in the pressenceof allergy to any of these drugs to preventhypersensitivity reactionsThese drugs are also contraindicated duringpregnacy.

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Term
Spring
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Angiotensin II receptor antagonist

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