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Running head:Picot Statement and Literature Search 1 Picot Statement and Literature Search Name Institution Date
Picot Statement and Literature Search PICOT STATEMENT Population (P)- Patients with central line associated bloodstream infections. Intervention (I)- Use of CLABSI bundle protocol Comparison (C)- No protocol Outcome (O)- Decreased rates of CLABSI infections in patients Time (T): During hospital stay LITERATURE SEARCH Patel, P. A., Boehm, S., Zhou, Y., Zhu, C., Peterson, K. E., Grayes, A., & Peterson, L. R. (2017). Major Article: Prospective observational study on central line–associated bloodstream infections and central venous catheter occlusions using a negative displacement connector with an alcohol disinfecting cap. AJIC: American Journal Of Infection Control, 45115-120. doi:10.1016/j.ajic.2016.06.013 Abstract Major complications in use of central venous catheter include bloodstream infection and occlusion. The article performed a prospective, observational study in determining the rate of central line–associated bloodstream infection as well as CVC occlusion using a negative displacement connector with an alcohol disinfecting cap. Patients were followed from the time of CVC insertion through 2 days after removal, at the time of hospital discharge if there was no documentation of removal. CLABSI was defined using National Healthcare Safety Network criteria. Data for evidence of lumen occlusions were extracted from the electronic health record. 2
Picot Statement and Literature Search Direct observations were performed to assess adherence to hospital policy regarding CVC insertion practice. Kramer, R. D., Conte, M., Mann, J., Saint, S., Chopra, V. (2017). Are antimicrobial peripherally inserted central catheters associated with reduction in central line–associated bloodstream infection? A systematic review and meta-analysis. American Journal of Infection Control, 45, 108-114. Abstract Antimicrobial peripherally inserted central catheters (PICCs) may reduce the risk of central line-associated bloodstream infection (CLABSI). However, data regarding efficacy are

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