WEEK 12_GASTRO_STUDENT.ppt - Chapter 57 Drugs Affecting Gastrointestinal Secretions Copyright \u00a9 2013 Wolters Kluwer Health | Lippincott Williams

WEEK 12_GASTRO_STUDENT.ppt - Chapter 57 Drugs Affecting...

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 57: Drugs Affecting Gastrointestinal Secretions Chapter 57: Drugs Affecting Gastrointestinal Secretions
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Peptic Ulcer Disease Peptic Ulcer Disease Definition Erosions in the lining of the stomach and adjacent areas of the GI tract Symptoms Gnawing, burning pain, often occurring after meals Cause Bacterial infection by Helicobacter pylori bacteria
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Drugs Used in the Treatment of Ulcers Drugs Used in the Treatment of Ulcers Histamine-2 (H 2 ) Antagonists Block the release of hydrochloric acid in response to gastrin Antacids Interact with acids at the chemical level to neutralize them Proton Pump Inhibitors Suppress the secretion of hydrochloric acid into the lumen of the stomach
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Drugs Used in the Treatment of Ulcers (cont.) Drugs Used in the Treatment of Ulcers (cont.) Antipeptic Agents Coat any injured area in the stomach to prevent further injury from acid Prostaglandins Inhibit the secretion of gastrin and increase the secretion of the mucous lining of the stomach, providing a buffer
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Sites of Actions of Drugs Affecting Gastrointestinal Secretions Sites of Actions of Drugs Affecting Gastrointestinal Secretions
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Histamine-2 (H 2 ) Antagonists Histamine-2 (H 2 ) Antagonists Block the release of hydrochloric acid in response to gastrin Cimetidine ( Tagamet HB ) Ranitidine ( Zantac ) Famo tidine ( Pepcid ) Niza tidine ( Axid )
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Copyright © 2017 Wolters Kluwer • All Rights Reserved
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Histamine-2 (H 2 ) Antagonists (cont.) Histamine-2 (H 2 ) Antagonists (cont.) Indications (cont.) Treatment of erosive gastroesophageal reflux Relief of symptoms of heartburn, acid indigestion, and sour stomach (OTC preparations) Pharmacokinetics Readily absorbed after oral administration Metabolized in the liver and excreted in urine Contraindications Known allergy
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Copyright © 2017 Wolters Kluwer • All Rights Reserved Histamine-2 (H 2 ) Antagonists (cont.) Histamine-2 (H 2 ) Antagonists (cont.) Caution Pregnancy or lactation Hepatic or renal dysfunction Adverse Effects GI effects CNS effects Cardiac arrhythmias and hypotension Drug-to-Drug Interactions Warfarin, phenytoin, beta blockers, alcohol, quinidine, lidocaine,
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