Quiz 2 Review.docx - Quiz 2 Review Muscular rings o...

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Quiz 2 Review Muscular rings: o Esophageal o Pyloric Chief cells enzymes Parietal cells HCL Protection thick mucus layer and bicarbonate PUD gastric or duodenal Risk factors: o Family Hx, Type O blood, smoking, caffeine, drugs (steroids, NSAIDS, platelet inhibitor), stress, H. Pylori gram negative OTHER excess acid, low mucus, NSAIDS DRUGS: o Proton pump inhibitors Prototype: Omeprazole (Prilosec) PO 20-60mg 1 to 2 times a day Adverse headache, diarrhea, nausea, rash, dizziness, Abd pain, Vomiting (GI disturbance) o SERIOUS Risk of osteoporosis (hip, wrist, spine fx) Atrophic gastritis, hypomagnesemia Contraindicated Allergies! MOA Reduce acid secretion by binding to enzyme H-K ATPase Limited to 2 months Short term 4-8 week for PUD and GERD o Most pts symptom free in 2 weeks Long term Gastric cancer monitor liver function and serum gastrin THERAPEUTIC Antiulcer drug PHARMACOLOGICAL
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